Volume 39, Issue 6 p. 537-543
Article

Effects of specific conjugated linoleic acid isomers on growth characteristics in obese Zucker rats

Sara R. Sanders

Sara R. Sanders

Department of Animal Sciences, University of Arizona, P.O. Box 210038 RM 22885721, 1200 E. South Campus Dr., Tucson, Arizona

Search for more papers by this author
Mary K. Teachey

Mary K. Teachey

Department of Physiology, University of Arizona, P.O. Box 210038 RM 228, 1200 E. South Campus Dr., Tucson, Arizona, 85721

Search for more papers by this author
Arne Ptock

Arne Ptock

BASF AG, Ludwigshafen, Germany

Search for more papers by this author
Klaus Kraemer

Klaus Kraemer

BASF AG, Ludwigshafen, Germany

Search for more papers by this author
Oliver Hasselwander

Oliver Hasselwander

BASF AG, Ludwigshafen, Germany

Search for more papers by this author
Erik J. Henriksen

Erik J. Henriksen

Department of Physiology, University of Arizona, P.O. Box 210038 RM 228, 1200 E. South Campus Dr., Tucson, Arizona, 85721

Search for more papers by this author
Lance H. Baumgard

Corresponding Author

Lance H. Baumgard

Department of Animal Sciences, University of Arizona, P.O. Box 210038 RM 22885721, 1200 E. South Campus Dr., Tucson, Arizona

To whom correspondence should be addressed at the University of Arizona, 1200 E. South Campus Dr., P.O. Box 210038 RM 228, Tucson, AZ 85721. E-mail: [email protected]Search for more papers by this author
First published: 01 June 2004
Citations: 12

Abstract

Growing female obese Zucker (fa/fa) rats were treated (via intragastric gavage) for 21 d with either a (i) vehicle [corn oil; 0.9 g/kg body weight (BW)], (ii) CLA mixture [50∶50; trans-10,cis-12 and cis-9,trans-11 CLA], (iii) cis-9,trans-11 CLA, or (iv) trans-10,cis-12 CLA (CLA treatments at 1.5 g CLA/kg BW). Compared with controls, average daily gain (g/d) was reduced 24 and 44% by the CLA mixture and trans-10,cis-12 CLA, respectively There was no treatment effect on average whole-body (minus heart and liver) composition (dry matter basis): fat (70.2%), protein (21.0%), and ash (4.3%). Compared with animals treated with cis-9,trans-11 CLA, obese Zucker rats treated with trans-10,cis-12 and the CLA mixture had 7.8% more carcass water. Treatment had no effect on heart or liver weights or on heart or liver weights as a percentage of body weight, but compared with the other treatments trans-10,cis-12 CLA increased liver lipid contentby 33%. Hepatic lipid ratios of 16∶1/16∶0 and 18∶1/18∶0 (a proxy for Δ9-desaturase capability) were not affected by treatment (0.1 and 0.6, respectively). Simlar to previous reports, CLA increased hepatic lipid content and altered both liver and carcass FA composition (i.e., reduced arachidonic acid content), but the ability of CLA to manipulate body composition in obese Zucker rats remains questionable.